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Ireland head coach Scott Bemand has made two changes as his side target a second successive win over South Africa in Cape Town.
Niamh Gallagher replaces Stacey Flood at full-back while Aoibheann Reilly is recalled at scrum-half as Emily Lane drops to the bench.
Trailfinders' Gallagher is joined by Beibhinn Parsons and Robyn O'Connor in the back three, while Anna McGann and Aoife Dalton continue in midfield.
Dannah O'Brien keeps the 10 jersey after kicking 10 points in last week's 40-27 win over the Springboks at Athlone Stadium.
Linda Djougang - who scored two tries last week - Neve Jones and Eilis Cahill line out in an unchanged front row, in front of locks Jane Clohessy and Dorothy Wall.
Fiona Tuite-O'Sullivan, captain Erin King and Brittany Hogan comprise the back row.
Ulster prop Sophie Barrett is in line for her second Test cap off the bench as Sadhbh McGrath drops out of the matchday 23.
Ireland: Niamh Gallagher; Beibhinn Parsons, Anna McGann, Aoife Dalton, Robyn O'Connor; Dannah O'Brien, Aoibheann Reilly; Linda Djougang, Neve Jones, Eilis Cahill, Jane Clohessy, Dorothy Wall, Fiona Tuite-O'Sullivan, Erin King (capt), Brittany Hogan.
Replacements: Beth Buttimer, Niamh O'Dowd, Sophie Barrett, Grace Moore, Jemima Adams Verling, Emily Lane, Eve Higgins, Stacey Flood.