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The Premier League champions travel to Germany to face Bayern Munich for the third season running.
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It follows a 3-1 home win for the Gunners during the league phase last term.
However, they have only won one of their previous seven away matches against Bayern as well as being winless in their last four visits to the Allianz Arena.
Mikel Arteta's side will also come up against Harry Kane, who has scored 15 goals in 22 matches against Arsenal during his career.
The England captain has only scored more times against Leicester City (20) and Everton (16).
Kane's form against the Gunners since joining Bayern has been less prolific, though, with one goal in three matches since his move from Tottenham Hotspur.
Despite that, his nine goals in 10 appearances across all competitions this season will provide enough of a warning for the visitors.
Arsenal travel to Germany on Wednesday, October 21 for their third match in this season's Champions League league phase.
Kick-off against Bayern is scheduled for 8pm, with live commentary available on talkSPORT.
Adrian Durham presents coverage of the match from 7pm.
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Bayern will be without France international Michael Olise on Wednesday through suspension.
The winger was sent off in their 3-3 draw with Viking last week.
Meanwhile, Jamal Musiala has been ruled out for the home side with a thigh injury.
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Last five meetings
November 2025: Arsenal 3-1 Bayern Munich
April 2024: Bayern Munich 1-0 Arsenal
April 2024: Arsenal 2-2 Bayern Munich
March 2017: Arsenal 1-5 Bayern Munich
February 2017: Bayern Munich 5-1 Arsenal
Manuel Neuer is expected to start in goal despite doubts over a foot issue which saw him miss Saturday's win over RB Leipzig.
As for Arsenal, there are no fresh injury concerns or suspensions for the Gunners.
Arteta remains without the sidelined Piero Hincapie, William Saliba and Christos Tzolis, though.
Arsenal will be hoping to maintain their 100 per cent record in their absence after wins over Napoli and Lille already this season.