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Real Madrid won every single match throughout October, a flawless run headlined by their 2-1 'Clasico' triumph over Barcelona at Camp Nou, alongside victories against Villarreal (1-0) and Sevilla (4-1).
The accolade is the first Jose Mourinho has collected in this category this season, recognising the "excellent performance of his team" at this stage of the competition.
Mourinho succeeds Barcelona boss Hansi Flick, who won the very award in September.