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ESPN predicts Colorado vs. Houston football matchup in Week 11

Colorado's 2026 season is on the brink, with three games left and three wins needed for a bowl berth. The first of the three games is by far the most challenging, with No. 14 Houston (7-2, 4-2 Big 12), one of the top teams in the Big 12 Conference.

The Buffaloes (3-6, 1-5 Big 12) enter the matchup desperately needing a win, but ESPN's Matchup Predictor overwhelmingly favors the Cougars despite it being a Friday night road game in Boulder.

Colorado's biggest task is slowing down Houston quarterback Conner Weigman, a dynamic dual-threat signal-caller who has only thrown two interceptions this season. His top playmaker is Amare Thomas, who has 47 receptions for 698 yards and eight touchdowns. Tight end Patrick Overmyer is a red zone threat with seven scores.

Offensively, Colorado will want to establish its ground game, but against a Houston defense that ranks third in the Big 12 and allows just 107.3 yards per game, that could be a challenge. The Cougars' secondary is an area the Buffs can attack, giving up the fourth-most passing yards per game (253 ypg).

The question remains: can Colorado quarterback Isaac Wilson be relied upon to carry the offense when the running game struggles without turning the ball over? So far, he hasn't proven he can, but if he can against Houston, Colorado will have a chance at the upset.

Here's how a few ESPN analytic models view the game playing out:

ESPN predicts Colorado vs. Houston

  • Offense ranking: Colorado (No. 101), Houston (No. 14)

  • Defense ranking: Colorado (No. 74), Houston (No. 45)

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