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The hosts have won just one of their opening four matches under the Belgian, but will be boosted by Scott McTominay's return and Andy Robertson's chance to equal Sir Kenny Dalglish's record of 102 caps.
Here's everything you need to know ahead of the clash.
Scotland face North Macedonia on Friday, November 13, at Hampden Park in Glasgow.
Kick-off is scheduled for 7.45pm.
Yes. The match will be broadcast live on BBC Scotland and BBC Two.
Coverage on BBC Scotland is scheduled to begin at 7.30pm, 15 minutes before kick-off.
Yes. Supporters can watch the match live through BBC iPlayer on compatible devices, including smartphones, tablets, laptops and smart televisions.
The game will also be available through the BBC Sport website.