The 49ers ruled out three wide receivers and have another who is questionable.

Mike Evans (Achilles), Deebo Samuel (hamstring) and Christian Kirk (knee) will not play against the Raiders. Demarcus Robinson (ankle) is questionable.

Coach Kyle Shanahan said Kirk injured his meniscus earlier this week but provided no details.

Evans has not played since Oct. 19 when he aggravated his Achilles. Samuel has not played since Oct. 11 when he strained his hamstring.

Evans has 27 receptions for 420 yards and three touchdowns, and Samuel has 16 catches for 206 yards and three touchdowns.

Safety Marques Sigle (ankle), defensive back Upton Stout (shoulder), defensive back Siran Neal (knee/foot) and cornerback Nate Hobbs (adductor) are questionable.

Defensive end Nick Bosa (knee/calf) has no injury designation, meaning he is expected to play for the first time since injuring his calf in Week 3.