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The draw is taking place at Bolitho Park, home of seventh-tier Plymouth Parkway, before they take on Berkhamsted in the final 1st round tie on Monday night.
Plymouth Argyle head coach and two-time FA Cup finalist Tom Cleverley will appear live on TNT Sport, ahead of the FA Cup second round draw.
What chances a Plymouth v Plymouth tie?
Two seasons ago Argyle reached the fifth round, taking the lead but losing 3-1 to Manchester City.
They knocked out Premier League sides Brentford and Liverpool on their run.