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Wycombe took a fifth minute lead through Connor Taylor converting from close range from a corner, after Louie Moulden had done well to deny Emre Tezgel to earn it.
But Stanley held their own for the remainder of the half and carved out some decent openings, albeit without testing goalkeeper Joe Wildsmith.
Charlie Warren came the closest but had his effort blocked off the line by a defender, while both he and Tyler Walton were unlucky not to connect with a Devon Matthews cross at the far left post - the delivery just evading them both.
The next goal was crucial, and it went the way of Wycombe, although they had to wait until after the hour mark to get it.
The visitors had been forced into their first change after losing former Burnley and Liverpool striker Danny Ings to a knock before the half-hour mark, but then made a tactical double substitution in the 62nd minute. And just seven minutes later they were celebrating their second goal as Stanley again came unstuck from another set piece, with Daniel Harvie heading in a Luke Leahy corner.
Wycombe's threat in those moments came as no surprise to Accrington Stanley manager John Doolan, with the visitors top in League One for goals scored from set pieces.
"We said that was going to be massive," said Doolan. "They haven't really posed any questions in open play.
"We've had moments that we haven't taken and they've taken theirs from two set plays; two corners.
"I don't think we asked their keeper that many questions, but I thought we played well in the first half.
"I thought we had opportunities we didn't take, which isn't like us, we normally pepper the goal, put loads of crosses into the box, get loads of shots off. I think there were moments in the game where we could have scored and we didn't with the chances that we did create, but we just missed them.
"Second half it was a little bit of the same again. Fine margins really. And then to get done on two set plays was disappointing because we've been really solid, and the home form as
"We knew it would be fine margins, we knew it would be set plays, we knew everyone had to do their job, but sometimes there are blocks in there, sometimes someone just out-jumps someone. You've got to try your best and the lads try and do that so we can't fault them for that.
"It's disappointing that we've lost our unbeaten run, but in the league we've got to continue that now."