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Michigan State vs. Northwestern: Score predictions, analysis from Spartans Wire staff

Check out our predictions for this week's matchup between Michigan State and Northwestern

Can Michigan State football find a way to get their season back on track this week against the ranked Northwestern Wildcats? The Spartans Wire crew has their thoughts about that.

Michigan State will once again look to snap a lengthy losing streak, with No. 25 Northwestern coming to town this weekend. The Spartans come into this matchup in the midst of a four-game losing streak following an overtime loss to Illinois last weekend. Michigan State is 2-4 overall and 0-3 in Big Ten play this year.

Northwestern, conversely, is playing well and climbed into the top 25 rankings of the media poll. The Wildcats are 4-1 overall and 1-1 in Big Ten play. Their lone loss was a strong showing at defending national champion Indiana.

Kickoff for this matchup is scheduled for 12 p.m. ET on Saturday. The game will be streamed on Peacock.

Let's take a look at our predictions for this week's matchup between Michigan State and Northwestern below:

Andrew Brewster

Michigan State Spartans head coach Pat Fitzgerald protests calls that went against the Michigan State Spartans during the fourth quarter against Illinois Fighting Illini on Oct 10, 2026; at Spartan Stadium.

Northwestern is having a great season. Michigan State was already feeling a talent crunch BEFORE injuries started to take their toll.

Cory Linsner

Michigan State’s head coach Pat Fitzgerald reacts after a penalty during the fourth quarter in the game against Illinois on Saturday, Oct. 10, 2026, at Spartan Stadium in East Lansing.

MSU is battered, beaten and just plain bad. Find it hard to believe they keep this one competitive.

Robert Bondy

Michigan State’s Jaziun Patterson celebrates his touchdown against Illinois during the fourth quarter on Saturday, Oct. 10, 2026, at Spartan Stadium in East Lansing.

Water has to find its level at some point. Aidan Chiles has yet to throw an interception this season, and that will eventually change. Put me down for an inspired effort from the Spartans and a few key turnovers being the difference in this upset win.

Rest of our Big Ten picks

Oct 3, 2026; Piscataway, New Jersey, USA; Indiana Hoosiers wide receiver Nick Marsh (11) in action against the Rutgers Scarlet Knights during the second half at SHI Stadium. Mandatory Credit: Vincent Carchietta-Imagn Images

Interested in our picks for the rest of the Big Ten games this week? Click here to check out our picks against the spread for each Big Ten game on the schedule this week.

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