• Sage loses 3-2 to former side; Leverkusen go top

• Alphadjo Cissè lights up 4-0 away victory

Crystal Palace’s Pierre Sage suffered a frustrating Europa League defeat as his side lost 3-2 to his former employers Lyon at the Groupama Stadium.

Corentin Tolisso opened the scoring for the hosts and Ernest Nuamah doubled Lyon’s advantage late in a first half void of any shots on target for the visitors.

Yéremy Pino cut the deficit in half five minutes after the break before Pavel Sulc restored the Ligue 1 side’s advantage. The Eagles substitute Daichi Kamada pulled one back with nine minutes remaining in a better second half for Palace, who could not find a third.

Days after beating his predecessor, the Nottingham Forest manager, Oliver Glasner, at Selhurst Park in the Premier League on Sunday, Sage found himself returning to the home of the club he managed for 14 months.

Ismaïla Sarr, who claimed the Conference League golden boot last season, was in a Crystal Palace starting lineup for the first time this season.

Milan cruised to a 4-0 victory at Red Bull Salzburg, courtesy of a hat-trick scored by Italian teenager Alphadjo Cissè.

Club-record signing Gonçalo Ramos made it four on 72 minutes before a red card for Filippo Terracciano took some of the sheen off the win for Ruben Amorim’s men.

Bayer Leverkusen sit pretty at the top of the standings as they followed up their opening 2-0 win with a 4-0 success at Polish side Lech Poznan.

Czech striker Patrik Schick was on target twice from the penalty spot in the first half, either side of a Malik Tillman goal, to ensure the points were wrapped up for Carles Martínez’s side before the interval. Ibrahim Maza added a late fourth.

Real Sociedad followed up their matchday one loss at home to Bournemouth with a 1-1 draw at Union Saint-Gilloise.

Later, Celtic travel to Lisbon to take on Benfica and Celta Vigo host Italian giants Juventus.