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The British titans renew their hostilities at London's O2 Arena for the WBO heavyweight title that Dubois snatched from Wardley last time out in May.
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That night, Dubois picked himself up off the canvas twice to stop Wardley against the ropes in the eleventh round of a gruelling Fight of the Year contender.
While the big men are undoubtedly the star attractions of the show, there are a couple of compelling matchups on the undercard.
And here, talkSPORT.com gives you the lowdown on the other action on offer.
In the co-main event, Louie O'Doherty puts his British and Commonwealth lightweight titles on the line against Michael Gomez Jr.
O'Doherty (12-0) picked up the British strap last October by halting Regan Glackin inside 10 rounds before adding the Commonwealth belt to his collection with a unanimous decision win over Ahmed Hatim.
Gomez Jr (23-2) failed to capture the British and Commonwealth titles at super featherweight against Reece Belloti in February 2025, but will now get a second crack a weight division above after besting Jordan Flynn and Lee McGregor in back-to-back bouts.
The fight promises to produce fireworks with both men known for their aggressive front-foot fighting.
It's a very different flavour in the antepenultimate bout of the evening, which pits two heavyweight boxer-movers against one another in Bakhodir Jalolov and Sol Dacres.
Jalolov (17-0) won gold at both Tokyo 2020 and Paris 2024, and had been tipped as the heir apparent to the heavyweight throne in the paid ranks.
However, a combination of lacklustre performances and the distraction of balancing both amateur and professional careers simultaneously has slowed his momentum.
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Main card
Prelims
Former English heavyweight champion Dacres (10-1) had been widely written off after his first-round knockout loss to David Adeleye in December 2024.
Yet he proved his detractors wrong by springing an upset over the previously unbeaten Vladyslav Sirenko last July on the Oleksandr Usyk vs Dubois II bill at Wembley Stadium.
The main card also features Roy Jones Jr's protege Tony Curtis (14-1), who boxes Kerim Agius (6-1-2) at super flyweight.
DAZN's broadcast is then capped off by a lightweight bout between former amateur standout Leighton Birchall and Alejandro Morales Chazaro.
Leighton's brother, Nelson (12-0), is also on the card, as is 20-year-old Irish heavyweight sensation Adam Olaniyan (4-0) and the debut of European Under 19 gold medallist Manny Safari (0-0)
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talkSPORT will have wall-to-wall coverage of the event, both on air and on our website.
Live commentary gets underway at 7pm BST (2pm EDT, 1pm CDT) on talkSPORT 2 before crossing over to talkSPORT from 9pm BST (4pm EDT, 3pm CDT) for the main event.
There will also be a watchalong on the talkSPORT Boxing YouTube channel and on Samsung TV Plus.
Listen to talkSPORT through the website or find us on DAB digital radio through your smart speaker and on 1089 or 1053 AM.
You can also download and listen to all our live commentaries via the talkSPORT app.
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