Davante Adams has ruptured his hamstring and is set to miss up to 10 weeks in a devastating blow for the Los Angeles Rams.

The veteran wide receiver suffered the injury late in the Rams' clash with the Arizona Cardinals on Sunday as Los Angeles fell to a surprising defeat, marking their fourth loss of the season.

The Rams kicked off the campaign as overwhelming Super Bowl favorites following trades for Myles Garrett and coaxing Aaron Donald back from retirement. However, they now confront a steep climb just to secure a playoff berth with four defeats on their ledger and a matchup against the Las Vegas Raiders looming this weekend. It comes as NFL confirms punishment for Bills star after gross incident.

Head coach Sean McVay confirmed the franchise absorbed a double setback, losing Adams for six-to-10 weeks due to a ruptured hamstring, while kicker Blake Grupe's season is finished after tearing his ACL.

The Rams have leaned heavily on Adams as their go-to red-zone weapon since his arrival last year, recording 18 touchdowns across 18 games.

Adams has maintained elite performance despite approaching his 34th birthday in the coming months, with only seven receivers league-wide accumulating more yardage than the six-time Pro Bowler.

Los Angeles must now count on Puka Nacua, who has battled injuries early this season, amid concerns he's dealing with a 'pre-hernia' - which carries a risk of developing into a hernia.

Nacua and Adams have spearheaded the Rams' offensive attack over the previous two seasons, and the organization must now weigh potential trade options to fill the void. The Rams have committed fully to this season's campaign after surrendering a first, second, and third-round draft selection, along with emerging pass-rusher Jared Verse, to acquire Myles Garrett.

Additionally, they parted with another first-round pick to secure cornerback Trent McDuffie from the Kansas City Chiefs.

Los Angeles may turn to free agency to bolster their receiving corps, with Tyreek Hill remaining unsigned and currently embroiled in legal proceedings.

The trade market could also present opportunities, as multiple franchises may consider moving players following their early-season performance.

The NFC appears accessible for the Rams to mount a late-season push, particularly as their division rival and reigning Super Bowl champion Seattle Seahawks are also faltering, stumbling to a 3-3 start to open the campaign.