Packers running back Josh Jacobs’ first carry of the season has taken center Sean Rhyan off the field.

Jacobs and Lions edge rusher Aidan Hutchinson rolled over Rhyan’s left ankle from behind.

The Packers list Rhyan as questionable to return with an ankle injury.

Jacob Monk, who lost his starting right guard job after three games, replaced Rhyan at center. But he didn’t last long, leaving with a quadriceps injury.

Monk, too, is questionable to return.

John Williams went in at center for the Packers’ second series. Williams had not previously snapped in any game, including the preseason.

The Packers did just fine, driving 74 yards in 12 plays to tie the game 7-7 on Tucker Kraft’s 14-yard reception from Jordan Love. Love is 10-of-14 for 122 yards and a touchdown. The Packers should have scored on their first possession, but rookie Trey Smack missed a 26-yard field goal.