Voltar
Scotland wing Duhan van der Merwe is set to make his first appearance of the season.
It comes as league leaders Edinburgh aim to maintain their perfect start in the United Rugby Championship at home to the Lions on Friday.
The 31-year-old missed the start of the campaign with an ankle injury but returns in place of Malelili Satala as one of four changes to the starting XV from the side that lost to Toulon in the Challenge Cup.
Geordie Gwynn, who scored his first Edinburgh try last Friday, comes in on the opposite wing in place of Darcy Graham, who misses out due to calf tightness.
Forwards Grant Gilchrist and Liam McConnell are also added while lock Marshall Sykes will make his 100th appearance for the club.
"We have always had tough games against the Lions. They have a good team with a strong set-piece and are a threat in transitions," said Edinburgh head coach Sean Everitt.
"We need an accurate performance to get the result.
"It's a big moment for Marshall to hit 100 appearances for the club. He has shown huge amounts of commitment to the jersey during his time in Edinburgh, and it's an achievement that everyone at the club is proud of him for."
There will be a minute's applause in the fifth minute in memory of Lions lock Hyron Andrews, who died last week.