According to a report by Madrid Universal on Wednesday October 21, 2026, Real Madrid defender Antonio Rudiger is expected to return to the starting lineup for the Champions League clash against RB Leipzig as Jose Mourinho prepares his team for another important European test.

According to reports, the German international is tipped to start alongside Ibrahima Konate in central defence, with Mourinho looking to establish the right defensive combination ahead of Sunday's El Clasico against Barcelona.

Rudiger has been rotating with Dean Huijsen for playing time, but his experience and physical presence could give him the advantage for the encounter with Leipzig.

The potential partnership with Konate would provide Madrid with two physically imposing defenders capable of competing in individual duels and dealing with opposition attacks.

Konate is also set for a significant reunion, having previously played for Leipzig before moving to Liverpool in 2021. The Frenchman is expected to retain his place as Madrid look to secure another victory in the Champions League.

Meanwhile, Denzel Dumfries is reportedly the favourite to start at right-back, while Marc Cucurella is expected to occupy the opposite flank, with Thibaut Courtois providing cover in goal.

Rudiger's possible return comes at an important time for Madrid, with the upcoming El Clasico likely to influence Mourinho's defensive decisions.

The German defender's aggression, strength in one-on-one situations and experience in high-pressure matches could prove valuable against Barcelona's attacking movement and pace.

However, the Leipzig fixture will give Mourinho an opportunity to assess how Rudiger and Konate work together, particularly when defending space behind the back line and building attacks from defence.

A convincing performance from the pair could strengthen their chances of featuring together against Barcelona, although Mourinho will also need to consider their fitness following the European encounter.

Madrid's immediate priority will be to overcome Leipzig, but Sunday's showdown against their fiercest rivals adds further significance to the defensive selection.