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England have confirmed an updated squad ahead of their clash with Japan this weekend, with six players stood down, including two who will miss the remainder of the Nations Championship.
Steve Borthwick's side will be without Immanuel Feyi-Waboso for the rest of the autumn after the winger suffered an ankle injury during the first half of England's 45-22 victory over Australia.
The injury is a major setback for England, particularly given Feyi-Waboso's impressive performance before being forced off. The winger looked dangerous throughout his time on the pitch and even had a try ruled out.
He will be replaced by Noah Caluori, who caught the eye with two tries in England A's victory over Argentina XV at The Rec on Friday night.
Sale Sharks flanker Tom Curry is the other player ruled out for the remainder of the autumn. Curry pulled up during training and removed himself from the session, with the hip injury understood to be unrelated to contact.
Three further players will miss the Japan fixture but are expected to return for England's meeting with the All Blacks at Allianz Stadium the following week.
Seb Atkinson limped off against Australia with a hip injury, while Ollie Chessum is nursing a shoulder problem and George Furbank has a groin issue.
Chessum particularly will be a huge miss for Borthwick, as he has established himself as one of the first names on the teamsheet at either lock or blindside flanker.
The Leicester Tigers captain brings plenty of physicality to the side and appears to be a good leader.
England will be hoping that he returns for the All Blacks visit in a couple of weeks.
Max Ojomoh, Max Hicks and Tobias Elliott have been brought into the squad to replace the trio, with all three having featured for England A against Argentina XV on Friday.
Young scrum-half Archie McParland has also returned from injury to replace Harry Randall, while Harlequins back row Jack Kenningham has been included following his involvement with England A as cover for Curry.