The Serie A side stunned Old Trafford in the first half, going into the break with a two-goal lead.

But the Red Devils turned it around after the break.

Bruno Fernandes' retaken penalty pulled one back, before Matheus Cunha's stunning brace sealed the victory.

In the other games played that night, Barcelona beat Aston Villa 3-0 at the Camp Nou and current holders Paris Saint-Germain thrashed Villarreal 6-0 in Spain.

Bayern Munich needed late goals to see off Atletico Madrid 2-0, and Inter Milan won 3-0 at Feyenoord.